Biological Small-Angle Neutron Scattering Instrument
Mission Statement
Bio-SANS is designed and optimized for analysis of the structure and function of complex biological systems.
Instrument Description
The Bio-SANS instrument is dedicated to structural analysis of complex biological systems. It is part of the Center for Structural Molecular Biology (CSMB) at Oak Ridge National Laboratory along with the Bio-Deuteration Laboratory (BDL). The Bio-SANS instrument, with its dual detector system, offers users a wide dynamic Q-range (~300) in a single exposure. Users can avail a variety of sample environments for static and in-operando measurements of biomacromolecules and biomaterials.
Applications
- Biomacromolecules and their assemblies
- Protein/nucleic acid/lipid complexes
- Biomembranes
- Membrane proteins
- Liposomes
- Nanodiscs
- Complex Systems
- In-Cellulo studies
- Viruses
- Biomass & Biofuels
- Plant cell wall structure & dynamics
- Biomimetic/Bioinspired Systems
- Microemulsions
- Micellar systems
- Gels & fibers
Specifications
| Wavelength | 6 < λ < 25 Å |
| Wavelength resolution | Δλ ⁄ λ = 9 – 45% |
| Q range | 0.0009 – 1 Å-1 |
| Sample-to-detector distance | 2.25 – 15.5 m |
| Detector | 2-D linear position-sensitive detector |
| Detector size | Main detector 1 × 1 m² Wide angle detector 1 x 0.8 m² |
| Detector resolution | Main detector 192 × 256 pixels Wide angle detector 160 x 256 pixels |
| Max count rate | 1 MHz |
BIO-SANS Instrument Team
Please select link below to email the instrument team. Be sure to include your name and email address.
Information and Guidance for Bio-SANS Users
Announcements
SAXS and SANS Joint Access Pilot Program
A pilot program for joint access to SAXS and SANS has been established between the Bio-SANS beam line at HFIR and the state-of-art LiX beam line at NSLS-II.
The users still submit beam time applications through existing regular proposal mechanisms with either facility (PASS system at BNL; IPTS system at ORNL). In the proposal system, the user needs to choose the additional facility desired to access and to justify the request for the other facility explicitly in the proposal text. In particular, they would address the necessity of using the other kind of probe.
Proposals may be accepted at one facility and declined for the other facility. Only proposals approved at both facilities are eligible for the pilot joint access program. Beam line scientists from both beam lines will coordinate with users for beam time allocation and beam line access.
For more information on the program, please contact Bio-SANS beam line scientist Wellington Leite ([email protected]).
Data Reduction Quick References
Bio-SANS Data Reduction: Jupyter Notebook
Bio-SANS Data Reduction: Parameters
Tutorials
JoVE Tutorial
Ryan C. OliverSwe-Htet NaingKevin L. WeissSai Venkatesh PingaliRaquel L. LiebermanVolker S. Urban